Joseph C. Corbo, MD, PhD
Professor, Pathology & Immunology
- Phone: 314-362-6254
- Email: jcorbo@nospam.wustl.edu
Division
- Neuropathology
Additional Titles
- Professor, Genetics
- Professor, Ophthamology and Visual Sciences
Related Links
Education
- PhD, Biology: U.C. San Diego, La Jolla, CA (1997)
- Medical Degree: U.C. San Diego, La Jolla, CA (1999)
- Resident in Anatomic Pathology: Brigham and Women’s Hospital, Boston, MA (2001)
- Clinical Fellow in Neuropathology: Brigham and Women’s Hospital, Boston, MA (2003)
- Research Post-doctoral Fellow, Department of Genetics: Harvard Medical School, Boston, MA (2005)
Board Certifications
- Neuropathology: Board Certified
- Anatomic Pathology: Board Certified
Recognition
- Japan Society for Promotion of Science, short-term fellowship (Kyoto, Japan), 1997
- Medical Scientist Training Program, U. C. San Diego, 1992 – 1999
- Regents Scholarship, University of California, 1991
- Lucille P. Markey Charitable Trust Fellowship, 1992 – 1996
- Firestone Medal for Outstanding Undergraduate Honors Thesis, Stanford University, 1990
- Award for Academic Excellence in the Freshman Year, Stanford University, 1987
Clinical Interests
- Neuropathology
Research Interests
We are poised on the threshold of a new era in medicine in which whole-genome sequencing will be a clinical reality. One of our lab’s major goals is to leverage this revolution in sequencing technology to predict and prevent disease. Up to now, our approach has been to elucidate the architecture of the transcriptional networks of the retina, with a particular focus on photoreceptors. We utilize this knowledge to build new technologies for mapping genotype onto phenotype and to devise cellular reprogramming strategies and optogenetic approaches to treat retinal disease. These translational strategies for retinal disease are complemented by other studies in the lab that focus on the basic biology of photoreceptors. Our research is strongly interdisciplinary and collaborative, with current projects that lie at the intersection of photoreceptor biology with chemistry and physics. By combining both basic and translational approaches, our lab aims to achieve a systems-level understanding of the development, diseases, function, evolution, and diversity of photoreceptors, and to extend this approach to other organ systems.
Selected Publications
| Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Volkov LI, Ogawa Y, Somjee R, Vedder HE, Powell HE, Poria D, Meiselman S, Kefalov VJ, Corbo JC.Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2402121121. doi: 10.1073/pnas.2402121121. Epub 2024 Nov 12.PMID: 39531499 |
| A molecular mechanism for bright color variation in parrots. Arbore R, Barbosa S, Brejcha J, Ogawa Y, Liu Y, Nicolaï MPJ, Pereira P, Sabatino SJ, Cloutier A, Poon ESK, Marques CI, Andrade P, Debruyn G, Afonso S, Afonso R, Roy SG, Abdu U, Lopes RJ, Mojzeš P, Maršík P, Sin SYW, White MA, Araújo PM, Corbo JC, Carneiro M.Science. 2024 Nov;386(6721):eadp7710. doi: 10.1126/science.adp7710. Epub 2024 Nov 1.PMID: 39480920 |
| Germline knockout of Nr2e3 protects photoreceptors in three distinct mouse models of retinal degeneration. Kolesnikov AV, Murphy DP, Corbo JC, Kefalov VJ.Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2316118121. doi: 10.1073/pnas.2316118121. Epub 2024 Mar 5.PMID: 38442152 |
| Transcription factor interactions explain the context-dependent activity of CRX binding sites. Loell KJ, Friedman RZ, Myers CA, Corbo JC, Cohen BA, White MA.PLoS Comput Biol. 2024 Jan 16;20(1):e1011802. doi: 10.1371/journal.pcbi.1011802. eCollection 2024 Jan.PMID: 38227575 |
| Enzymatic vitamin A2 production enables red-shifted optogenetics. Gerhards J, Volkov LI, Corbo JC, Malan D, Sasse P.Pflugers Arch. 2023 Dec;475(12):1409-1419. doi: 10.1007/s00424-023-02880-2. Epub 2023 Nov 21.PMID: 37987804 |
| Active learning of enhancer and silencer regulatory grammar in photoreceptors. Friedman RZ, Ramu A, Lichtarge S, Myers CA, Granas DM, Gause M, Corbo JC, Cohen BA, White MA.bioRxiv [Preprint]. 2023 Aug 22:2023.08.21.554146. doi: 10.1101/2023.08.21.554146.PMID: 37662358 |
| A single-cell massively parallel reporter assay detects cell-type-specific gene regulation. Zhao S, Hong CKY, Myers CA, Granas DM, White MA, Corbo JC, Cohen BA.Nat Genet. 2023 Feb;55(2):346-354. doi: 10.1038/s41588-022-01278-7. Epub 2023 Jan 12.PMID: 36635387 |
| A mechanism for red coloration in vertebrates. Toomey MB, Marques CI, Araújo PM, Huang D, Zhong S, Liu Y, Schreiner GD, Myers CA, Pereira P, Afonso S, Andrade P, Gazda MA, Lopes RJ, Viegas I, Koch RE, Haynes ME, Smith DJ, Ogawa Y, Murphy D, Kopec RE, Parichy DM, Carneiro M, Corbo JC.Curr Biol. 2022 Oct 10;32(19):4201-4214.e12. doi: 10.1016/j.cub.2022.08.013. Epub 2022 Aug 31.PMID: 36049480 |
| Information content differentiates enhancers from silencers in mouse photoreceptors. Friedman RZ, Granas DM, Myers CA, Corbo JC, Cohen BA, White MA.Elife. 2021 Sep 6;10:e67403. doi: 10.7554/eLife.67403.PMID: 34486522 |
| Partitioning of gene expression among zebrafish photoreceptor subtypes. Ogawa Y, Corbo JC.Sci Rep. 2021 Aug 30;11(1):17340. doi: 10.1038/s41598-021-96837-z.PMID: 34462505 |
Assistant
Jaden Mocumbi
314-273-8627
Jadenm@wustl.edu
BJCIH, Room 3405